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Estrogen and progesterone improve scopolamine-induced impairment of spatial memory
https://tmdu.repo.nii.ac.jp/records/240
https://tmdu.repo.nii.ac.jp/records/240070c75cd-2a42-42aa-869a-e7e634f8f504
名前 / ファイル | ライセンス | アクション |
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12_tanabe (743.4 kB)
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Copyright © 2004 Tokyo Medical and Dental University (TMDU)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2017-08-15 | |||||
タイトル | ||||||
タイトル | ||||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | estrogen | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | progesterone | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | scopolamine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | working memory | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | radial maze | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | estrogen | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | progesterone | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | scopolamine | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | working memory | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | radial maze | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
田辺, 文子
× 田辺, 文子× 宮坂, 尚幸× 久保田, 俊郎× 麻生, 武志 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | This study was conducted to investigate the effects of estrogen and progesterone on spatial memory in ovariectomized female rats, specifically, on memory impaired by the cholinergic antagonist scopolamine. Forty-one female rats were divided into five groups: ovariectomized (OVX), estrogen-treated after ovariectomy (OE), progesterone-treated after ovariectomy (OP), estrogen-progesterone-treated after ovariectomy (OEP), and the sham control group (Control). The animals were trained on an eight-arm radial maze with four arms baited to assess both working and reference memory performances. The OE and OEP groups showed significant improvement in the ability to perform a spatial memory task over the OVX group (P<0.05). Spatial memory in the OP group did not differ from that in the OVX group. After thirty-two trials were conducted and all rats learned the eight-radial maze task, scopolamine hydrobromide (0.2 mg/kg i.p.) was administered prior to retesting. After scopolamine injection, the OVX group showed an increased number of working memory errors, reference memory errors than the other groups (P< 0.05). The OE, OEP and OP groups showed significant improvement in spatial impairment induced by scopolamine. These finding ssuggest progesterone alone or in combination with estrogen, improved scopolamine-induced impairment of working memory and reference memory as effectively as estrogen supplementation. | |||||
書誌情報 |
Journal of Medical and Dental Sciences en : Journal of medical and dental sciences 巻 51, 号 1, p. 89-98, 発行日 2004-03 |
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出版者 | ||||||
出版者 | 東京医科歯科大学 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2185-9132 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12028964 | |||||
論文ID(NAID) | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | NAID | |||||
関連識別子 | 110000076056 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 15137470 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.11480/jmds.510112 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |