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TARC and MDC are produced by CD40 activated human B cells and are elevated in the sera of infantile atopic dermatitis patients.
https://tmdu.repo.nii.ac.jp/records/257
https://tmdu.repo.nii.ac.jp/records/2578c944ad9-9280-45a5-a6cb-406b1ca729a9
名前 / ファイル | ライセンス | アクション |
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04_Lin (325.7 kB)
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Copyright © 2003 Tokyo Medical and Dental University (TMDU)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2017-08-15 | |||||
タイトル | ||||||
タイトル | ||||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | TARC | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | MDC | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IgE | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | atopic dermatitis | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | TARC | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | MDC | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | IgE | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | atopic dermatitis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Lin, Lin
× Lin, Lin× 野々山, 恵章× 大柴, 晃洋× 椛沢, 靖弘× 水谷, 修紀 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We report here that human B cells produce thymus and activation-regulated chemokine (TARC/CCL17) and macrophage derived chemokine (MDC/CCL22) if stimulated with anti-CD40 and IL-4. The production was determined by both protein and mRNA level using specific ELISA and semi-quantitative RT-PCR methods. Since the ligand of the TARC and MDC is CCR4, which is specifically expressed on Th2 type T cells, the production of these CC chemokines is likely to play important roles in the T cell and B cell interaction. Consistent with this, ovalbumin (OVA) specific IgE levels, which reflect the T-B cell interaction, are significantly correlated with the amounts of TARC and MDC in sera. Furthermore, we found that TARC and MDC levels are significantly increased in the sera obtained from patients with atopic dermatitis, and that the amounts are correlated with the severity of atopic dermatitis. Since CD40 ligand and IL-4 are produced by activated T helper cells, these results indicate that TARC and MDC produced by B cells play important roles in the production of antigen specific IgE by the T-B cell interaction and in the pathogenesis of allergic disease. | |||||
書誌情報 |
Journal of Medical and Dental Sciences en : Journal of Medical and Dental Sciences 巻 50, 号 1, p. 27-33, 発行日 2003-03 |
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出版者 | ||||||
出版者 | 東京医科歯科大学 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2185-9132 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12028964 | |||||
論文ID(NAID) | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | NAID | |||||
関連識別子 | 130005172521 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 12715916 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.11480/jmds.500104 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |