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Exposure of neonatal rats to diethylstilbestrol affects the expression of genes involved in ovarian differentiation
https://tmdu.repo.nii.ac.jp/records/258
https://tmdu.repo.nii.ac.jp/records/2588996c84c-8b63-4026-ad8d-5909a0f66743
名前 / ファイル | ライセンス | アクション |
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05_Nagai (137.4 kB)
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Copyright © 2003 Tokyo Medical and Dental University (TMDU)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2017-08-15 | |||||
タイトル | ||||||
タイトル | ||||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | diethylstilbestrol (DES) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | rat ovary | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | RT-PCR | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | in situ hybridization | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | immunohistochemistry | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | diethylstilbestrol (DES) | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | rat ovary | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | RT-PCR | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | in situ hybridization | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | immunohistochemistry | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
永井, 亜希子
× 永井, 亜希子× 池田, やよい× 麻生, 武志× 江藤, 一洋× 池田, 正明 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Exposing neonatal rats with the synthetic estrogen, diethylstilbestrol (DES), induces morphological and functional abnormalities in the adult ovary. We examined the events that lead to this condition using female rats that were exposed to DES for the first five days after birth. The expression of steroidogenic acute regulatory protein (StAR) and cholesterol side-chain cleavage cytochrome P450 (P450scc), which are both required for steroidogenesis in the theca/interstitial region was markedly reduced. The expression of Müllerian inhibiting substance (MIS) was transiently increased in small growing follicles in the ovary of DES-treated rats at postnatal day 7 (P7), and the expression profile in the ovary differed between DES- and vehicle oil-treated rats at P14 and P21. The expression of the transcription factor, steroidogenic factor-1 (SF-1), reduced in theca/interstitial cells, but increased in granulosa cells of primary follicles. These results indicate that altered steroidogenesis and MIS production are mechanisms through which DES induces abnormal ovarian development, and support the notion that androgens and MIS are both critical factors in regulating early ovarian differentiation. | |||||
書誌情報 |
Journal of Medical and Dental Sciences en : Journal of medical and dental sciences 巻 50, 号 1, p. 35-40, 発行日 2003-03 |
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出版者 | ||||||
出版者 | 東京医科歯科大学 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2185-9132 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12028964 | |||||
論文ID(NAID) | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | NAID | |||||
関連識別子 | 110000076015 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 12715917 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.11480/jmds.500105 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |