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アイテム
Doublecortin-like kinase 1 expression is induced by alternative NF-κB signaling in human lung cancer cells
https://tmdu.repo.nii.ac.jp/records/803
https://tmdu.repo.nii.ac.jp/records/803276f7cd4-c915-4bb4-b139-67f5e7f289f4
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
05_Lu (1.7 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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| 公開日 | 2021-03-05 | |||||||||||||
| タイトル | ||||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | Doublecortin-like kinase 1 | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | Idiopathic pulmonary fibrosis | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | IL17 | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | Lymphotoxin-α | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | NF-κB | |||||||||||||
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| 主題 | RELA | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | RELB | |||||||||||||
| 公開日 | ||||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | journal article | |||||||||||||
| 著者 |
Lu, Yuxiong
× Lu, Yuxiong
× Maruyama, Junichi
× Sugimura, Haruhiko
× Hata, Yutaka
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| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Idiopathic pulmonary fibrosis (IPF), a devastating fibrotic lung disease of unknown etiology, is frequently associated with lung cancer. However, the molecular mechanism underlying this association remains unclear. We analyzed the gene expression profiles of IPF lungs using public datasets and extracted 94 genes that were upregulated in all of them. Among these, we identified DCLK1, a wellknown cancer stem cell-marker. A recent study revealed that DCLK1 enhances cancer stem cell-like features in lung cancer cells. Therefore, if DCLK1 expression is induced in IPF, it could be a molecular link between IPF and lung cancers. In this study, we confirmed that DCLK1 expression was enhanced in human IPF lungs and in lungs of mice with bleomycin- induced fibrosis. We also found that the human lung cancer H1299 cells expressed DCLK1 when exposed to the conditioned medium derived from the lipopolysaccharide-stimulated murine macrophage- like RAW264.7 cells. Further, this DCLK1-inducing activity was sensitive to heat inactivation and proteinase K treatment. We also revealed that IL17 and lymphotoxin-α induced DCLK1 expression in human lung cancer H1299 cells. Moreover, RELB silencing, but not RELA silencing, blocked the induction of DCLK1 expression by conditioned medium. Hence, the inhibition of alternative NF-κB signaling may be useful to prevent cancer development in IPF lungs. | |||||||||||||
| 書誌情報 |
Journal of Medical and Dental Sciences 巻 68, p. 39-48, 発行日 2021-03 |
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| 出版者 | Tokyo Medical and Dental University | |||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 2185-9132 | |||||||||||||
| DOI | ||||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | 10.11480/jmds.680005 | |||||||||||||
