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Chronic sun exposure shortens telomeres of the epidermis
https://tmdu.repo.nii.ac.jp/records/820
https://tmdu.repo.nii.ac.jp/records/820b5cbe5d1-4f23-4ca6-afab-72f1e6ab601c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
09_Tatsumi (1.6 MB)
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Copyright ©2021 Tokyo Medical and Dental University (TMDU)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
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| 公開日 | 2021-05-31 | |||||||||||
| タイトル | ||||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| キーワード | ||||||||||||
| 主題 | Telomere | |||||||||||
| キーワード | ||||||||||||
| 主題 | Skin aging | |||||||||||
| キーワード | ||||||||||||
| 主題 | Q-FISH | |||||||||||
| キーワード | ||||||||||||
| 主題 | Ultraviolet | |||||||||||
| 公開日 | ||||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 著者 |
Tatsumi, Akiya
× Tatsumi, Akiya
× Sawabe, Motoji
× Aida, Junko
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| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | The ends of human chromosome are protected by telomeres, which are composed of tandem repeats of DNA sequences. Telomeres can be damaged by a variety of environmental factors, ultimately resulting in cellular senescence and carcinogenesis. The purpose of this study was to clarify the relationship between telomere shortening in the skin and sun exposure. Using quantitative fluorescence in situ hybridization (Q-FISH), we examined telomere lengths (TL) in the epidermis and dermis of sun-exposed (SE) and sun non-exposed (NE) skin from the same individuals without any skin disease. There was a significant difference (p = 0.039) in epidermal TL between SE and NE samples, except for adolescents and young adults (AYA). Our results suggest that chronic sun exposure shortens the telomeres of the epidermis, which may explain the UV-associated acceleration of skin aging and skin disorders. | |||||||||||
| 書誌情報 |
Journal of Medical and Dental Sciences 巻 68, p. 75-83, 発行日 2021-05 |
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| 出版者 | Tokyo Medical and Dental University | |||||||||||
| ISSN | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 2185-9132 | |||||||||||
| DOI | ||||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | 10.11480/jmds.680009 | |||||||||||
