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HER-2/neu cytoplasmic staining is correlated with neuroendocrine differentiation in breast carcinoma
https://tmdu.repo.nii.ac.jp/records/89
https://tmdu.repo.nii.ac.jp/records/894b62d70e-3597-4654-9901-dd5eabff9b1d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
05_S.Horiguchi (6.8 MB)
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Copyright © 2010 Tokyo Medical and Dental University (TMDU)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-08-07 | |||||
| タイトル | ||||||
| タイトル | HER-2/neu cytoplasmic staining is correlated with neuroendocrine differentiation in breast carcinoma | |||||
| タイトル | ||||||
| タイトル | HER-2/neu cytoplasmic staining is correlated with neuroendocrine differentiation in breast carcinoma | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | HER2/neu | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cytoplasmic staining | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | neuroendocrine differentiation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | breast cancer | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | immunohistochemistry | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | HER2/neu | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | cytoplasmic staining | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | neuroendocrine differentiation | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | breast cancer | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | immunohistochemistry | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
堀口, 慎一郎
× 堀口, 慎一郎× 比島, 恒和× 林, 幸子× 塩沢, 由美子× 堀口, 和美× 黒井, 克昌× 戸井, 雅和× 船田, 信顕× 江石, 義信 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | HER2 oncoprotein plays an essential role in breast cancer growth and differentiation. Determination of HER2 status contributes not only to predicting survival but also to selecting the patients for anti-HER2 therapy. HER2 protein expressed in human cancer cells often contains variant forms as well as the full-length wild-type form. In the present study, we investigated the subcellular localization of HER2 protein in 1053 primary breast cancer tissues. HER2 protein was stained by various immunohistochemical methods and studied by immunoelectron microscopy to confirm the intracellular localization. Thirty-four of 1053 specimens showed cytoplasmic staining of the intracellular domain of HER2 protein by the HercepTest® and CB-11. In contrast, no immunoreactivity to the antibodies against the extracellular domain was observed. None of the 34 specimens showed amplification of the HER2 protein by fluorescence in situ hybridization. Subsequently, we studied the association of the cytoplasmic expression of HER2 with neuroendocrine differentiation. Interestingly, all 34 specimens had some positive signals of neuroendocrine markers such as synaptophysin, chromogranin A, neuron-specific enolase, and CD56. Although the result is preliminary, it warrants further study on the role of the cytoplasmic variant form of HER2 in breast cancer growth, particularly in the aspect of neuroendocrine differentiation. | |||||
| 書誌情報 |
Journal of Medical and Dental Sciences en : Journal of medical and dental sciences 巻 57, 号 2, p. 155-163, 発行日 2010-06 |
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| 出版者 | ||||||
| 出版者 | 国立大学法人 東京医科歯科大学 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2185-9132 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA12028964 | |||||
| 論文ID（NAID） | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | NAID | |||||
| 関連識別子 | 110007617695 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 21073134 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.11480/jmds.570205 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
