{"created":"2023-05-15T09:23:06.361362+00:00","id":240,"links":{},"metadata":{"_buckets":{"deposit":"3b33a114-9042-42d2-9cb7-340c7e4b1465"},"_deposit":{"created_by":11,"id":"240","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"240"},"status":"published"},"_oai":{"id":"oai:tmdu.repo.nii.ac.jp:00000240","sets":["5:40:80"]},"author_link":["2322","193","660","657"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"98","bibliographicPageStart":"89","bibliographicVolumeNumber":"51","bibliographic_titles":[{"bibliographic_title":"Journal of Medical and Dental Sciences"},{"bibliographic_title":"Journal of medical and dental sciences","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"This study was conducted to investigate the effects of estrogen and progesterone on spatial memory in ovariectomized female rats, specifically, on memory impaired by the cholinergic antagonist scopolamine. Forty-one female rats were divided into five groups: ovariectomized (OVX), estrogen-treated after ovariectomy (OE), progesterone-treated after ovariectomy (OP), estrogen-progesterone-treated after ovariectomy (OEP), and the sham control group (Control). The animals were trained on an eight-arm radial maze with four arms baited to assess both working and reference memory performances. The OE and OEP groups showed significant improvement in the ability to perform a spatial memory task over the OVX group (P<0.05). Spatial memory in the OP group did not differ from that in the OVX group. After thirty-two trials were conducted and all rats learned the eight-radial maze task, scopolamine hydrobromide (0.2 mg/kg i.p.) was administered prior to retesting. After scopolamine injection, the OVX group showed an increased number of working memory errors, reference memory errors than the other groups (P< 0.05). The OE, OEP and OP groups showed significant improvement in spatial impairment induced by scopolamine. These finding ssuggest progesterone alone or in combination with estrogen, improved scopolamine-induced impairment of working memory and reference memory as effectively as estrogen supplementation.","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東京医科歯科大学"}]},"item_10002_relation_12":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"110000076056","subitem_relation_type_select":"NAID"}}]},"item_10002_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"15137470","subitem_relation_type_select":"PMID"}}]},"item_10002_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.11480/jmds.510112","subitem_relation_type_select":"DOI"}}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12028964","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2185-9132","subitem_source_identifier_type":"ISSN"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田辺, 文子"},{"creatorName":"Tanabe, Fumiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"宮坂, 尚幸"},{"creatorName":"Miyasaka, Naoyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"久保田, 俊郎"},{"creatorName":"Kubota, Toshiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"麻生, 武志"},{"creatorName":"Aso, Takeshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-08-15"}],"displaytype":"detail","filename":"12_tanabe.pdf","filesize":[{"value":"743.4 kB"}],"format":"application/pdf","license_note":"Copyright © 2004 Tokyo Medical and Dental University (TMDU) ","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"12_tanabe","url":"https://tmdu.repo.nii.ac.jp/record/240/files/12_tanabe.pdf"},"version_id":"b3d9b8c6-2f3f-4992-93e5-ff805b1fffda"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"estrogen","subitem_subject_scheme":"Other"},{"subitem_subject":"progesterone","subitem_subject_scheme":"Other"},{"subitem_subject":"scopolamine","subitem_subject_scheme":"Other"},{"subitem_subject":"working memory","subitem_subject_scheme":"Other"},{"subitem_subject":"radial maze","subitem_subject_scheme":"Other"},{"subitem_subject":"estrogen","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"progesterone","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"scopolamine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"working memory","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"radial maze","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Estrogen and progesterone improve scopolamine-induced impairment of spatial memory","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{},{}]},"item_type_id":"10002","owner":"11","path":["80"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-08-15"},"publish_date":"2017-08-15","publish_status":"0","recid":"240","relation_version_is_last":true,"title":["Estrogen and progesterone improve scopolamine-induced impairment of spatial memory"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-05-15T09:43:36.527724+00:00"}