@article{oai:tmdu.repo.nii.ac.jp:00000294,
 author = {後藤, 方通 and Gotoh, Masamichi and 野呂, 信弘 and Noro, Nobuhiro and 佐原, 資謹 and Sahara, Yoshinori},
 issue = {1},
 journal = {Journal of Medical and Dental Sciences, Journal of Medical and Dental Sciences},
 month = {Mar},
 note = {The kinetic properties of tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) Na+ channels in acutely dissociated neonatal rat trigeminal ganglion neurons were studied using whole-cell and cell-attached patch-clamp recordings. The time course of TTX-R currents was slower than that of TTX-S currents. Compared with TTX-S currents, TTX-R currents had more positive half-activation and half-inactivation voltages. TTX-R currents recovered from inactivation much faster than TTX-S currents. Cell-attached patch recordings showed that the slope conductance of single TTX-S and TTX-R channels was 14.6 pS and 7.8 pS, respectively. TTX-R channels had longer open-times and more dispersed latent-times than TTX-S channels. The convolution of the first latency distribution with the open-time distribution revealed that the slower time course of TTX-R currents is due to longer open-times and more dispersed latent-times of the TTX-R channels compared with those of the TTX-S channels. These findings suggest that TTX-R Na+ channels in trigeminal ganglion neurons have similar kinetic property to brain TTX-S Na+ channels, but not to structurally homologous cardiac Na+ channels.},
 pages = {43--55},
 volume = {49},
 year = {2002}
}