{"created":"2023-05-15T09:23:09.329356+00:00","id":294,"links":{},"metadata":{"_buckets":{"deposit":"2e584d0d-cc8c-4d01-bbdf-bad12d6674ec"},"_deposit":{"created_by":11,"id":"294","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"294"},"status":"published"},"_oai":{"id":"oai:tmdu.repo.nii.ac.jp:00000294","sets":["5:42:88"]},"author_link":["2833","2834","2835"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"55","bibliographicPageStart":"43","bibliographicVolumeNumber":"49","bibliographic_titles":[{"bibliographic_title":"Journal of Medical and Dental Sciences"},{"bibliographic_title":"Journal of Medical and Dental Sciences","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The kinetic properties of tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) Na+ channels in acutely dissociated neonatal rat trigeminal ganglion neurons were studied using whole-cell and cell-attached patch-clamp recordings. The time course of TTX-R currents was slower than that of TTX-S currents. Compared with TTX-S currents, TTX-R currents had more positive half-activation and half-inactivation voltages. TTX-R currents recovered from inactivation much faster than TTX-S currents. Cell-attached patch recordings showed that the slope conductance of single TTX-S and TTX-R channels was 14.6 pS and 7.8 pS, respectively. TTX-R channels had longer open-times and more dispersed latent-times than TTX-S channels. The convolution of the first latency distribution with the open-time distribution revealed that the slower time course of TTX-R currents is due to longer open-times and more dispersed latent-times of the TTX-R channels compared with those of the TTX-S channels. These findings suggest that TTX-R Na+ channels in trigeminal ganglion neurons have similar kinetic property to brain TTX-S Na+ channels, but not to structurally homologous cardiac Na+ channels.","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"国立大学法人 東京医科歯科大学"}]},"item_10002_relation_12":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"110000032770","subitem_relation_type_select":"NAID"}}]},"item_10002_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"12160226","subitem_relation_type_select":"PMID"}}]},"item_10002_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.11480/jmds.490106","subitem_relation_type_select":"DOI"}}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2185-9132","subitem_source_identifier_type":"ISSN"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"後藤, 方通"},{"creatorName":"Gotoh, Masamichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"野呂, 信弘"},{"creatorName":"Noro, Nobuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"佐原, 資謹"},{"creatorName":"Sahara, Yoshinori","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-08-16"}],"displaytype":"detail","filename":"06_Gotoh.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","license_note":"Copyright © 2002 Tokyo Medical and Dental University (TMDU) ","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"06_Gotoh","url":"https://tmdu.repo.nii.ac.jp/record/294/files/06_Gotoh.pdf"},"version_id":"5ad89be5-17e4-42a4-96a0-2b83111fb96f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Whole-cell recording","subitem_subject_scheme":"Other"},{"subitem_subject":"Single-channel recording","subitem_subject_scheme":"Other"},{"subitem_subject":"Convolution","subitem_subject_scheme":"Other"},{"subitem_subject":"RT-PCR","subitem_subject_scheme":"Other"},{"subitem_subject":"Whole-cell recording","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Single-channel recording","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Convolution","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"RT-PCR","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Kinetic properties of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channel currents in neonatal rat trigeminal ganglion neurons","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{},{}]},"item_type_id":"10002","owner":"11","path":["88"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-08-16"},"publish_date":"2017-08-16","publish_status":"0","recid":"294","relation_version_is_last":true,"title":["Kinetic properties of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channel currents in neonatal rat trigeminal ganglion neurons"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-05-15T09:42:48.219936+00:00"}