{"created":"2023-05-15T09:23:18.743884+00:00","id":473,"links":{},"metadata":{"_buckets":{"deposit":"740b7ff0-c964-4aaf-964e-72223fb1c3c8"},"_deposit":{"created_by":3,"id":"473","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"473"},"status":"published"},"_oai":{"id":"oai:tmdu.repo.nii.ac.jp:00000473","sets":["132:145:146"]},"author_link":["4216","4219","4218","4217","4221","4220"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1995-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"29","bibliographicPageStart":"19","bibliographicVolumeNumber":"42","bibliographic_titles":[{"bibliographic_title":"The bulletin of Tokyo Medical and Dental University"}]}]},"item_10001_date_24":{"attribute_name":"公開日","attribute_value_mlt":[{}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Intracellular recordings were made from bullfrog sympathetic ganglion cells to elucidate effects of 2-n-butyl-1-(4-methylpiperazinyl)-5,6-methylenedioxyindene・2HCI (TN-871) on synaptic transmission. TN-871 at 30 nM augmented cholinergic nicotinic fast excitatory postsynaptic potentials (fast EPSPs), whereas the drug at 3 µM reversibly depressed them, without affecting acetylcholine induced depolarizations. TN-871 did not affect active and passive electrical properties of the ganglion cells. The quantal analysis method was applied to the fast EPSPs in a 0.54 mM Ca2+/7.56 mM Mg2+ Ringer’s solution. The mean quantal content was significantly increased by TN-871 at 30 nM but significantly at 3 µM. TN-871 at 300 nM either increased or decreased the mean quantal content. The mean quanta! size of the fast EPSPs was not changed by TN-871 at the concentrations examined. Fast EPSPs in a 0.99 mM Ca2+/4.86 mM Mg2+ Ringer’s solution were not decreased affected by nicardipine, but were inhibited in amplitude by w-conotoxin in a concentration­ dependent manner. It is likely that TN-871, in high concentrations, might block w-conotoxin­ sensitive N-type calcium channels in the presynaptic terminals. These results indicate that TN-871 modulates transmitter release from preganglionic nerve terminals without changing the postsynaptic sensitivity of the ganglion cells to ACh.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tokyo Medical and Dental University"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.11480/btmd.420103","subitem_relation_type_select":"DOI"}}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2435-0761","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ying-Lan, SHEN"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Keiji, HIRAI"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshifumi, KATAYAMA"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ying-Lan, SHEN","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Keiji, HIRAI","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshifumi, KATAYAMA","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-09-25"}],"displaytype":"detail","filename":"03_Shen.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"03_Shen.pdf","url":"https://tmdu.repo.nii.ac.jp/record/473/files/03_Shen.pdf"},"version_id":"f0273161-1020-4b09-87c8-6fead0d7a6b7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Intracellular recording"},{"subitem_subject":"Ganglionic transmission"},{"subitem_subject":"Sympathetic ganglion"},{"subitem_subject":"Fast EPSP"},{"subitem_subject":"Acetylcholine"},{"subitem_subject":"Quanta! analysis"},{"subitem_subject":"Transmitter release"},{"subitem_subject":"Indene-derivative"},{"subitem_subject":"TN-871"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"EFFECTS OF AN INDENE-DERIVATIVE, TN-871, ON SYNAPTIC TRANSMISSION IN A SYMPATHETIC GANGLION: PRESYNAPTIC ACTIONS ON NEUROTRANSMITTER RELEASE","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{}]},"item_type_id":"10001","owner":"3","path":["146"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-09-25"},"publish_date":"2019-09-25","publish_status":"0","recid":"473","relation_version_is_last":true,"title":["EFFECTS OF AN INDENE-DERIVATIVE, TN-871, ON SYNAPTIC TRANSMISSION IN A SYMPATHETIC GANGLION: PRESYNAPTIC ACTIONS ON NEUROTRANSMITTER RELEASE"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2024-03-06T08:00:48.865693+00:00"}