{"created":"2023-05-15T09:22:55.566140+00:00","id":60,"links":{},"metadata":{"_buckets":{"deposit":"ea62cfbe-2a48-458f-953b-a2c030bf7218"},"_deposit":{"created_by":11,"id":"60","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"60"},"status":"published"},"_oai":{"id":"oai:tmdu.repo.nii.ac.jp:00000060","sets":["5:30:51"]},"author_link":["522","134","313","515","518","310","311","517","308","137","136"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"16","bibliographicPageStart":"9","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"Journal of medical and dental sciences"},{"bibliographic_title":"Journal of medical and dental sciences","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Calcium alginate gel has some unique properties, such as the capability to keep the drugs, bioadhesiveness, safety, and low cost. The purpose of this study is to determine whether calcium alginate gel can be used as a matrix of electrodes for iontophoresis (IOP). We measured the concentration of lidocaine transported from calcium alginate gels with various concentrations of alginic acid using an in vitro experimental cell with square-wave alternating current (AC) application. Temperature and pH changes were also determined during AC-IOP. The results revealed that lidocaine was released from calcium alginate gels at concentrations nearly 1.71-fold larger at 5 V, 60 min after AC application than in the case of passive diffusion. Lidocaine transport depended on the alginic acid concentration in the gels. Although there were slight increases in temperature and pH, chemical and thermal burns were not severe enough to be a concern. In conclusion, the calcium alginate gel can be used as a possible matrix for IOP electrodes.","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"国立大学法人 東京医科歯科大学"}]},"item_10002_relation_12":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"110008904364","subitem_relation_type_select":"NAID"}}]},"item_10002_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"23896960","subitem_relation_type_select":"PMID"}}]},"item_10002_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.11480/jmds.590102","subitem_relation_type_select":"DOI"}}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12028964","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2185-9132","subitem_source_identifier_type":"ISSN"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"灰田, 悠"},{"creatorName":"Haida, Haruka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"308","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤, 寧"},{"creatorName":"Ando, Shizuka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"310","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大上, 沙央理"},{"creatorName":"Ogami, Saori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"515","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇田, 亮"},{"creatorName":"Wakita, Ryo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"136","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小長谷, 光"},{"creatorName":"Kohase, Hikaru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"517","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saito, Norio"},{"creatorName":"Saito, Norio","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"518","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉岡, 朋彦"},{"creatorName":"Yoshioka, Tomohiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"311","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"生駒, 俊之"},{"creatorName":"Ikoma, Toshiyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"134","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中, 順三"},{"creatorName":"Tanaka, Junzo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"313","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"海野, 雅浩"},{"creatorName":"Umino, Masahiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"522","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"深山, 治久"},{"creatorName":"Fukayama, Haruhisa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"137","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-08-07"}],"displaytype":"detail","filename":"02_Haida.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","license_note":"Copyright © 2012 Tokyo Medical and Dental University (TMDU) ","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"02_Haida","url":"https://tmdu.repo.nii.ac.jp/record/60/files/02_Haida.pdf"},"version_id":"e7ba4c6b-1eb7-4a3c-9aed-ee760d5c5802"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Drug delivery system (DDS)","subitem_subject_scheme":"Other"},{"subitem_subject":"Iontophoresis (IOP)","subitem_subject_scheme":"Other"},{"subitem_subject":"Calcium alginate gel","subitem_subject_scheme":"Other"},{"subitem_subject":"Alternating Current (AC)","subitem_subject_scheme":"Other"},{"subitem_subject":"Electrode","subitem_subject_scheme":"Other"},{"subitem_subject":"Drug delivery system (DDS)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Iontophoresis (IOP)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Calcium alginate gel","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Alternating Current (AC)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Electrode","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin 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