{"created":"2023-05-15T09:23:27.310843+00:00","id":630,"links":{},"metadata":{"_buckets":{"deposit":"3b147e06-36c6-4693-a092-318bd3dcb720"},"_deposit":{"created_by":11,"id":"630","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"630"},"status":"published"},"_oai":{"id":"oai:tmdu.repo.nii.ac.jp:00000630","sets":["5:218"]},"author_link":["5250","5251","5252","5253","5254","5255","5256"],"control_number":"630","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-02","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"10","bibliographicPageStart":"1","bibliographicVolumeNumber":"67","bibliographic_titles":[{"bibliographic_title":"Journal of Medical and Dental Sciences"}]}]},"item_10001_date_24":{"attribute_name":"公開日","attribute_value_mlt":[{}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Introduction: Cough variant asthma (CVA) and asthma account for a large proportion of patients with chronic cough. We used hierarchical cluster analysis (HCA) to characterize the phenotypes of patients with cough, mainly those with CVA, who showed a rapid response to asthma therapy, and sought to identify simple diagnostic markers. Methods: Patients who initially presented with cough as the main symptom were retrospectively enrolled. Those who were clinically diagnosed with asthma/CVA were selected and analyzed. HCA was performed and the patients were classified by phenotype. Results: HCA identified the five following phenotypes among the 221 participants: highly eosinophilic bronchitis [high fractional exhaled nitric oxide (FeNO) , n = 28]; atopic [high total serum IgE , n = 23]; non-atopic and non-eosinophilic [n = 104]; distal airway narrowing [low FEF75 (V ₂₅), n = 21] and severely atopic [extremely high total serum IgE and/or extreme high FeNO, n = 45]. No significant differences in long-term prognosis were found among the phenotypes. Discussion: Five phenotypes were identified among patients with cough who showed a rapid response to asthma treatment. Wheezing was observed in about 24% of patients, and abnormal FeNO or V₂₅ levels in about 30%.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tokyo Medical and Dental University"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.11480/jmds.670001","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright ©2020 Tokyo Medical and Dental University (TMDU)"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2185-9132","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Saki, Oyama"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshio, Otani"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wakaba, Furuie"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fumika, Koike"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takao, Miyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miho, Akaza"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yuki, Sumi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"コンテンツ本体","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-26"}],"displaytype":"detail","filename":"01_Oyama.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","license_note":"Copyright ©2020 Tokyo Medical and Dental University (TMDU)","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"01_Oyama.pdf","url":"https://tmdu.repo.nii.ac.jp/record/630/files/01_Oyama.pdf"},"version_id":"9a16da4e-f52e-480a-aeb3-21227ed2ac48"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cough variant asthma"},{"subitem_subject":"Asthma"},{"subitem_subject":"Phenotype"},{"subitem_subject":"FeNO"},{"subitem_subject":"Cluster analysis"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Cluster analysis of patients with cough, mainly cough variant asthma, showing a good response to asthma therapy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{}]},"item_type_id":"10001","owner":"11","path":["218"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-02-26"},"publish_date":"2020-02-26","publish_status":"0","recid":"630","relation_version_is_last":true,"title":["Cluster analysis of patients with cough, mainly cough variant asthma, showing a good response to asthma therapy"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2024-04-25T00:19:35.767800+00:00"}