@article{oai:tmdu.repo.nii.ac.jp:00000974,
 issue = {1},
 journal = {The bulletin of Tokyo Medical and Dental University},
 month = {Mar},
 note = {The purpose of the present study was to clarify the fundamental histological changes in endochondral ossification and their morphogenesis in 190 infants with various kinds of diseases ranging in ages from birth to 14 months and in 3 aborted fetuses. Histopathological examination was performed on the epiphyseal plate and its precursor, that is, the diaphyseal growing part of the cartilaginous epiphysis at the lower end of the femur. Before the development of the secondary ossification center, the diaphyseal growing part showed a less distinct zonal differentiation in structure. With the progressive development of the secondary ossification center, the epiphyseal plate became well differentiated and showed a typical zonal differentiation. The cluster pattern of the proliferating cartilage cells was characteristic in the fetal life. There was a close relationship between the cluster pattern and the insufficient development of the secondary ossification center. The present study revealed that the cluster pattern, disturbances in the proliferation of the cartilage cells and calcification of the cartilage were most fundamental and influential in morphogenesis of the histological changes in the endochondral ossification in the younger infants.},
 pages = {1--21},
 volume = {18},
 year = {1971}
}