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Cluster analysis of patients with cough, mainly cough variant asthma, showing a good response to asthma therapy
https://tmdu.repo.nii.ac.jp/records/630
https://tmdu.repo.nii.ac.jp/records/6302fb52d36-d382-4501-b618-a06add4850b5
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
01_Oyama.pdf (1.2 MB)
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Copyright ©2020 Tokyo Medical and Dental University (TMDU)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||
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| 公開日 | 2020-02-26 | |||||||||||||||||||
| タイトル | ||||||||||||||||||||
| 言語 | ||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題 | Cough variant asthma | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題 | Asthma | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題 | Phenotype | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題 | FeNO | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題 | Cluster analysis | |||||||||||||||||||
| 公開日 | ||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||
| 著者 |
Saki, Oyama
× Saki, Oyama
× Yoshio, Otani
× Wakaba, Furuie
× Fumika, Koike
× Takao, Miyoshi
× Miho, Akaza
× Yuki, Sumi
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| 抄録 | ||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||
| 内容記述 | Introduction: Cough variant asthma (CVA) and asthma account for a large proportion of patients with chronic cough. We used hierarchical cluster analysis (HCA) to characterize the phenotypes of patients with cough, mainly those with CVA, who showed a rapid response to asthma therapy, and sought to identify simple diagnostic markers. Methods: Patients who initially presented with cough as the main symptom were retrospectively enrolled. Those who were clinically diagnosed with asthma/CVA were selected and analyzed. HCA was performed and the patients were classified by phenotype. Results: HCA identified the five following phenotypes among the 221 participants: highly eosinophilic bronchitis [high fractional exhaled nitric oxide (FeNO) , n = 28]; atopic [high total serum IgE , n = 23]; non-atopic and non-eosinophilic [n = 104]; distal airway narrowing [low FEF75 (V ₂₅), n = 21] and severely atopic [extremely high total serum IgE and/or extreme high FeNO, n = 45]. No significant differences in long-term prognosis were found among the phenotypes. Discussion: Five phenotypes were identified among patients with cough who showed a rapid response to asthma treatment. Wheezing was observed in about 24% of patients, and abnormal FeNO or V₂₅ levels in about 30%. | |||||||||||||||||||
| 書誌情報 |
Journal of Medical and Dental Sciences 巻 67, p. 1-10, 発行日 2020-02 |
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| 出版者 | ||||||||||||||||||||
| 出版者 | Tokyo Medical and Dental University | |||||||||||||||||||
| ISSN | ||||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||||
| 収録物識別子 | 2185-9132 | |||||||||||||||||||
| DOI | ||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||
| 関連識別子 | 10.11480/jmds.670001 | |||||||||||||||||||
| 権利 | ||||||||||||||||||||
| 権利情報 | Copyright ©2020 Tokyo Medical and Dental University (TMDU) | |||||||||||||||||||
