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Solute carrier transporters, reduced folate carrier 1 and equilibrative nucleoside transporter 1, as immunohistochemical markers for high-grade malignancy in bladder cancer
https://tmdu.repo.nii.ac.jp/records/631
https://tmdu.repo.nii.ac.jp/records/631d22ac9b4-9bdb-4b2b-8324-4c0d06ecb6ad
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
02_Denda.pdf (924.8 kB)
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Copyright ©2020 Tokyo Medical and Dental University (TMDU)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||
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| 公開日 | 2020-02-26 | |||||||||||||||||||||
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| 言語 | ||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題 | Reduced folate carrier 1 | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題 | equilibrative nucleoside transporter 1 | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題 | solute carrier transporters | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題 | urinary bladder neoplasms | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題 | immunohistochemistry | |||||||||||||||||||||
| 公開日 | ||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||
| 著者 |
Tamami, Denda
× Tamami, Denda
× Shingo, Kamoshida
× Sadahito, Kuwao
× Jumpei, Kawamura
× Yasunori, Ota
× Yurie, Soejima
× Masako, Akiyama
× Motoji, Sawabe
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| 抄録 | ||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||
| 内容記述 | Clinicopathological parameters derived from initial transurethral resection of bladder tumor (TUR-Bt) have limitations in predicting tumor progression in bladder cancer. Reduced folate carrier 1 (RFC1) and equilibrative nucleoside transporter 1 (ENT1) are solute carrier (SLC) transporters supporting cellular uptake of endogenous bioactive substances and anti-cancer drugs. The aim of this study was to elucidate the role of SLC transporters in bladder cancer and investigate the potential of RFC1 and ENT1 expression as immunohistochemical markers for high-grade malignancy. We compared T-stage with the immunohistochemical expression of RFC1 and ENT1 and other clinicopathological parameters; moreover, we also used multiple logistic regression model to assess relative contributions for T-stage in bladder cancer (n=130). Concurrently, 57 TUR-Bt-derived imprint cytological samples were stained to evaluate the implication of cytological analysis. Elevated expression levels of RFC1 and ENT1 were significantly correlated with higher T-stage (p < .0001) and efficiently predicted tumor progression, compared with other clinicopathological parameters (RFC1, p = .0325; ENT1, p = .0171). Independent variables of optimal model for predicting T-stage were gender, age, histological grade, expression levels of RFC1 and ENT1. Cytological analysis was consistent with immunostained-tissue data. We reveal RFC1 and ENT1 as potential immunohistocytochemical markers for high-grade malignancy in bladder cancer. | |||||||||||||||||||||
| 書誌情報 |
Journal of Medical and Dental Sciences 巻 67, p. 11-20, 発行日 2020-02 |
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| 出版者 | ||||||||||||||||||||||
| 出版者 | Tokyo Medical and Dental University | |||||||||||||||||||||
| ISSN | ||||||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||||||
| 収録物識別子 | 2185-9132 | |||||||||||||||||||||
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| 識別子タイプ | DOI | |||||||||||||||||||||
| 関連識別子 | 10.11480/jmds.670002 | |||||||||||||||||||||
| 権利 | ||||||||||||||||||||||
| 権利情報 | Copyright ©2020 Tokyo Medical and Dental University (TMDU) | |||||||||||||||||||||
