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Kinetic properties of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channel currents in neonatal rat trigeminal ganglion neurons
https://tmdu.repo.nii.ac.jp/records/294
https://tmdu.repo.nii.ac.jp/records/294111969a3-05ac-43de-a754-427e20fbaef5
名前 / ファイル | ライセンス | アクション |
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06_Gotoh (1.7 MB)
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Copyright © 2002 Tokyo Medical and Dental University (TMDU)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2017-08-16 | |||||
タイトル | ||||||
タイトル | ||||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Whole-cell recording | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Single-channel recording | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Convolution | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | RT-PCR | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Whole-cell recording | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Single-channel recording | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Convolution | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | RT-PCR | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
後藤, 方通
× 後藤, 方通× 野呂, 信弘× 佐原, 資謹 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The kinetic properties of tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) Na+ channels in acutely dissociated neonatal rat trigeminal ganglion neurons were studied using whole-cell and cell-attached patch-clamp recordings. The time course of TTX-R currents was slower than that of TTX-S currents. Compared with TTX-S currents, TTX-R currents had more positive half-activation and half-inactivation voltages. TTX-R currents recovered from inactivation much faster than TTX-S currents. Cell-attached patch recordings showed that the slope conductance of single TTX-S and TTX-R channels was 14.6 pS and 7.8 pS, respectively. TTX-R channels had longer open-times and more dispersed latent-times than TTX-S channels. The convolution of the first latency distribution with the open-time distribution revealed that the slower time course of TTX-R currents is due to longer open-times and more dispersed latent-times of the TTX-R channels compared with those of the TTX-S channels. These findings suggest that TTX-R Na+ channels in trigeminal ganglion neurons have similar kinetic property to brain TTX-S Na+ channels, but not to structurally homologous cardiac Na+ channels. | |||||
書誌情報 |
Journal of Medical and Dental Sciences en : Journal of Medical and Dental Sciences 巻 49, 号 1, p. 43-55, 発行日 2002-03 |
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出版者 | ||||||
出版者 | 国立大学法人 東京医科歯科大学 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2185-9132 | |||||
論文ID(NAID) | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | NAID | |||||
関連識別子 | 110000032770 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 12160226 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.11480/jmds.490106 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |