WEKO3
インデックスリンク
アイテム
{"_buckets": {"deposit": "740b7ff0-c964-4aaf-964e-72223fb1c3c8"}, "_deposit": {"created_by": 3, "id": "473", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "473"}, "status": "published"}, "_oai": {"id": "oai:tmdu.repo.nii.ac.jp:00000473", "sets": ["146"]}, "author_link": ["4216", "4219", "4218", "4217", "4221", "4220"], "item_10001_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1995-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "29", "bibliographicPageStart": "19", "bibliographicVolumeNumber": "42", "bibliographic_titles": [{"bibliographic_title": "The bulletin of Tokyo Medical and Dental University"}]}]}, "item_10001_date_24": {"attribute_name": "公開日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "1995-03"}]}, "item_10001_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Intracellular recordings were made from bullfrog sympathetic ganglion cells to elucidate effects of 2-n-butyl-1-(4-methylpiperazinyl)-5,6-methylenedioxyindene・2HCI (TN-871) on synaptic transmission. TN-871 at 30 nM augmented cholinergic nicotinic fast excitatory postsynaptic potentials (fast EPSPs), whereas the drug at 3 µM reversibly depressed them, without affecting acetylcholine induced depolarizations. TN-871 did not affect active and passive electrical properties of the ganglion cells. The quantal analysis method was applied to the fast EPSPs in a 0.54 mM Ca2+/7.56 mM Mg2+ Ringer’s solution. The mean quantal content was significantly increased by TN-871 at 30 nM but significantly at 3 µM. TN-871 at 300 nM either increased or decreased the mean quantal content. The mean quanta! size of the fast EPSPs was not changed by TN-871 at the concentrations examined. Fast EPSPs in a 0.99 mM Ca2+/4.86 mM Mg2+ Ringer’s solution were not decreased affected by nicardipine, but were inhibited in amplitude by w-conotoxin in a concentration dependent manner. It is likely that TN-871, in high concentrations, might block w-conotoxin sensitive N-type calcium channels in the presynaptic terminals. These results indicate that TN-871 modulates transmitter release from preganglionic nerve terminals without changing the postsynaptic sensitivity of the ganglion cells to ACh.", "subitem_description_type": "Abstract"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Tokyo Medical and Dental University"}]}, "item_10001_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.11480/btmd.420103", "subitem_relation_type_select": "DOI"}}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2435-0761", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ying-Lan, SHEN"}], "nameIdentifiers": [{"nameIdentifier": "4216", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Keiji, HIRAI"}], "nameIdentifiers": [{"nameIdentifier": "4217", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshifumi, KATAYAMA"}], "nameIdentifiers": [{"nameIdentifier": "4218", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ying-Lan, SHEN", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4219", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Keiji, HIRAI", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4220", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshifumi, KATAYAMA", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4221", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-09-25"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "03_Shen.pdf", "filesize": [{"value": "1.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1100000.0, "url": {"label": "03_Shen.pdf", "url": "https://tmdu.repo.nii.ac.jp/record/473/files/03_Shen.pdf"}, "version_id": "f0273161-1020-4b09-87c8-6fead0d7a6b7"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Intracellular recording", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Ganglionic transmission", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Sympathetic ganglion", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Fast EPSP", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Acetylcholine", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Quanta! analysis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Transmitter release", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Indene-derivative", "subitem_subject_scheme": "Other"}, {"subitem_subject": "TN-871", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "EFFECTS OF AN INDENE-DERIVATIVE, TN-871, ON SYNAPTIC TRANSMISSION IN A SYMPATHETIC GANGLION: PRESYNAPTIC ACTIONS ON NEUROTRANSMITTER RELEASE", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "EFFECTS OF AN INDENE-DERIVATIVE, TN-871, ON SYNAPTIC TRANSMISSION IN A SYMPATHETIC GANGLION: PRESYNAPTIC ACTIONS ON NEUROTRANSMITTER RELEASE"}]}, "item_type_id": "10001", "owner": "3", "path": ["146"], "permalink_uri": "https://tmdu.repo.nii.ac.jp/records/473", "pubdate": {"attribute_name": "公開日", "attribute_value": "2019-09-25"}, "publish_date": "2019-09-25", "publish_status": "0", "recid": "473", "relation": {}, "relation_version_is_last": true, "title": ["EFFECTS OF AN INDENE-DERIVATIVE, TN-871, ON SYNAPTIC TRANSMISSION IN A SYMPATHETIC GANGLION: PRESYNAPTIC ACTIONS ON NEUROTRANSMITTER RELEASE"], "weko_shared_id": 3}
EFFECTS OF AN INDENE-DERIVATIVE, TN-871, ON SYNAPTIC TRANSMISSION IN A SYMPATHETIC GANGLION: PRESYNAPTIC ACTIONS ON NEUROTRANSMITTER RELEASE
https://tmdu.repo.nii.ac.jp/records/473
https://tmdu.repo.nii.ac.jp/records/47330eef212-b651-4471-b57d-3f9cf8063c8e
名前 / ファイル | ライセンス | アクション |
---|---|---|
03_Shen.pdf (1.1 MB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2019-09-25 | |||||
タイトル | ||||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | Intracellular recording | |||||
キーワード | ||||||
主題 | Ganglionic transmission | |||||
キーワード | ||||||
主題 | Sympathetic ganglion | |||||
キーワード | ||||||
主題 | Fast EPSP | |||||
キーワード | ||||||
主題 | Acetylcholine | |||||
キーワード | ||||||
主題 | Quanta! analysis | |||||
キーワード | ||||||
主題 | Transmitter release | |||||
キーワード | ||||||
主題 | Indene-derivative | |||||
キーワード | ||||||
主題 | TN-871 | |||||
公開日 | ||||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ying-Lan, SHEN
× Ying-Lan, SHEN× Keiji, HIRAI× Yoshifumi, KATAYAMA× Ying-Lan, SHEN× Keiji, HIRAI× Yoshifumi, KATAYAMA |
|||||
抄録 | ||||||
書誌情報 |
The bulletin of Tokyo Medical and Dental University 巻 42, 号 1, p. 19-29, 発行日 1995-03 |
|||||
出版者 | ||||||
出版者 | Tokyo Medical and Dental University | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2435-0761 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.11480/btmd.420103 |