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MECHANISM OF VITAMIN B12 MALABSORPTION IN BLIND LOOP SYNDROME: BACTERIAL UPTAKE OF VITAMIN B12 AND STABILITY OF BINDING OF VITAMIN B12 TO GASTRIC INTRINSIC FACTOR
https://tmdu.repo.nii.ac.jp/records/968
https://tmdu.repo.nii.ac.jp/records/96875d4c99b-4219-41e4-ac98-8ece7777c268
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
01_Nakajima.pdf (1.8 MB)
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Copyright ©1972 Tokyo Medical and Dental University (TMDU)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-09-30 | |||||
| タイトル | ||||||
| タイトル | MECHANISM OF VITAMIN B12 MALABSORPTION IN BLIND LOOP SYNDROME: BACTERIAL UPTAKE OF VITAMIN B12 AND STABILITY OF BINDING OF VITAMIN B12 TO GASTRIC INTRINSIC FACTOR | |||||
| 言語 | ||||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Roth free vitamin B12 (B12) and B12 bound to the intrinsic factor (IF) were taken up by the microorganisms. The amount of B12 taken up in the presence of IF was fairly smaller than in the absence of IF. The stability of the B12-IF complex was influenced by the temperature as well as by pH. The bacterial uptake of B12 appeared to be favourable under the condition where the vitamin dissociated easily from IF. Moreover, when the B12-IF complex was incubated with the microorganisms, the free IF activity in the supernatant increased according to the bacterial uptake of B12. It seemed that the microorganisms took up B12 after the liberation of B12 from IF. The amount of B12 available for bacterial uptake was regulated by the rate of dissociation of the B12-IF complex as well as by the reciprocal changes in the size of the bacterial population and IF available. It is suggested that R12 malabsorption in the blind loop syndrome could be partly explained by the bacterial uptake of B12 in the presence of abundant microorganisms in the loop and by the predominant dissociation of the vitamin from IF. | |||||
| 書誌情報 |
The bulletin of Tokyo Medical and Dental University 巻 19, 号 4, p. 311-331, 発行日 1972-12 |
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| 出版者 | ||||||
| 出版者 | Tokyo Medical and Dental University | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2435-0761 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.11480/btmd.190401 | |||||
| 権利 | ||||||
| 権利情報 | Copyright ©1972 Tokyo Medical and Dental University (TMDU) | |||||
